Hyperpolarizing GABAergic transmission depends on KCC2 function and membrane potential
نویسندگان
چکیده
منابع مشابه
Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain.
KCC2 is the neuron-specific member of the of K(+)-Cl(-) cotransporter gene family. It is also the only member of its family that is active under physiologically normal conditions, in the absence of osmotic stress. By extruding Cl(-) from the neuron under isotonic conditions, this transporter maintains a low concentration of neuronal Cl(-), which is essential for fast inhibitory synaptic transmi...
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The neuron-specific K-Cl cotransporter, KCC2, induces a developmental shift to render GABAergic transmission from depolarizing to hyperpolarizing. Now we demonstrate that KCC2, independently of its Cl(-) transport function, is a key factor in the maturation of dendritic spines. This morphogenic role of KCC2 in the development of excitatory synapses is mediated by structural interactions between...
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ژورنال
عنوان ژورنال: Channels
سال: 2011
ISSN: 1933-6950,1933-6969
DOI: 10.4161/chan.5.6.17952